This is such a fun word, I think.

discombobulate (dis·com·bob·u·late): / dis kuhm BOB yuh layt /
transitive verb

(1) to confuse or disconcert; to frustrate; to upset

[Etymology unknown. Probably an alteration of discompose, discomfort, or discomfit.]

Usage: Would you be discombobulated if we heckled you during your speech?